microRNA agomir synthesis

microRNA agomir synthesis

Agomir is a double stranded small RNA that has been specially labeled and chemically modified. It regulates the biological function of target genes by mimicking endogenous miRNAs. Compared with miRNA mimetics, agomir has higher stability and inhibitory effects, and can be enriched in target cells to achieve efficient and specific stable interference. It can be administered through various methods such as systemic injection or local injection, and the operation is simple. The agomir provided by Biosyntech has low toxicity and can be directly injected into experimental animals.

Agomir modification method is as follows:

Modification description: Agomir is modified on the antisense chain, cholesterol modification at the 3 'end, two phosphorothioate modifications at the 5' end, four phosphorothioate modifications at the 3 'end, and full chain methoxy modification.