siRNA Synthesis

RNA interference (RNAi) refers to the highly conserved and highly specific degradation of homologous mRNA induced by double stranded RNA (dsRNA) during evolution. It is currently widely used in fields such as drug development, gene function research, and target discovery.

Small interfering RNA (siRNA) refers to small fragments of RNA synthesized artificially in vitro during RNA interference, usually 19-23nt dsRNA. After being recognized and bound by RISC, siRNA undergoes melting, siRNA is unstranded, and the antisense strand can interact with the mRNA of the target gene, leading to mRNA degradation or transcriptional inhibition, thereby inhibiting the expression of the target gene (the mechanism of action is shown in the figure below).

Biosyntech can provide services such as siRNA design, synthesis, modification, and labeling. All siRNA products are purified using standard HPLC to achieve in vivo levels, making them suitable for various cell and animal experiments.

Mechanism of siRNA action

siRNA therapy has made significant progress in clinical research in recent years, and approved siRNA drugs include: